Canis ISSN: 2398-2942

Glipizide

Synonym(s): Glibenase, Minodiab

Contributor(s): Vetstream Ltd

Introduction

Name

  • Glipizide.

Class of drug

  • Sulfonylurea.

Description

Storage requirements

  • Keep cool.
  • Avoid moisture.

Uses

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Indications

  • Management of type-II or non-insulin dependent diabetes mellitus (NIDDM) Diabetes mellitus where there is some residual insulin production.
  • In these cases it may be effective alone or administered with insulin to reduce insulin requirements.
  • Glipizide is ineffective when there is an absolute insulin deficiency (IDDM) or when insulin resistance is present.

Administration

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Precautions

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Interactions

with other drugs

  • The effects of glipizide may be enhanced by ACE inhibitors, NSAIDs, chloramphenicol, potentiated sulfonamides and fluoroquinolones.
  • Hypoglycemia may be increased by cimetidine administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Feldman E C, Nelson R W & Feldman M S (1997) Intensive 50-week evaluation of glipizide administration in 50 cats with previously untreated diabetes mellitus. JAVMA 210 (6), 772-777 PubMed.
  • Nelson R W, Feldman E C, Ford S L et al (1993) Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. JAVMA 203 (6), 821-827 PubMed.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.

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