Canis ISSN: 2398-2942

Flunixin meglumine

Contributor(s): Kyle Braund, John Dodam

Introduction

Name

  • Flunixin meglumine.

Class of drug

Description

Chemical name

  • 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid.

Molecular formula

  • C14H11F3N2O2.C7H17NO5.

Physical properties

  • Pale sterile solution.
  • Tablets.

Storage requirements

  • Between 2-25°C.

Uses

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Indications

  • Flunixin controls moderate to severe visceral and somatic pain.
  • To minimize the effects of endotoxemia.
    Pretreatment is most effective.
  • Use of flunixin meglumine in small animal medicine has declined since the introduction of other NSAIDs with higher therapeutic indices.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Fluoroquinolones
  • In man there is an increased risk of convulsions if NSAIDs are administered with fluoroquinolones.
Anti-hypertensive agents
  • NSAIDs may antagonize the hypotensive effects of anti-hypertensives, eg beta-blockers.
Diuretics
  • The concomitant use of diuretics may increase the risk of nephrotoxicity.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Mathews K A (1996)Nonsteroidal anti-inflammatory analgesics to manage acute pain in dogs and cats.Comp Cont Educ Pract Vet18(10), 1117-1123.

Other sources of information

  • Based onSmall Animal Formulary.(1999) Tennant, Bryn 3rd edn. Cheltenham: BSAVA.

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