Canis ISSN: 2398-2942

Fluconazole

Introduction

Name

• Fluconazole.

Class of drug

• Triazole antifungal agent.

Uses

Indications

• Effective against Blastomyces Blastomyces dermatitidis , Candida Candida albicans , Cryptococcus Cryptococcus neoformans, Coccidioides, Histoplasma and Microspoum canis. Variably effective against Aspergillus and Penicillum infections.

Administration

Precautions

Interactions

with other drugs

Phenytoin

• Enhanced effects of phenytoin Phenytoin due to inhibition of cytochrome P450 dependent liver enzymes.

Theophylline

• Increased plasma concentrations of theophylline Theophylline.
• In man fluconazole has led to terfenadine Terfenadine toxicity when the two are administered together.

Adverse Reactions