Canis ISSN: 2398-2942

Felbamate

Synonym(s): Felbatol

Contributor(s): Simon Platt

Introduction

Name

  • IUPAC.

Class of drug

  • Anticonvulsant - dicarbamate.

Description

Chemical name

  • Trideca-1,3,11-trien-5,7,9-triyne.

Molecular formula

  • C11H14N2O4

Molecular weight

  • 238.24

Physical properties

  • White to off-white crystalline powder.

Storage requirements

  • Store in tightly closed container at room temperature away from heat and direct sunlight.

Uses

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Indications

  • Adjunct therapy for canine seizures refractory to standard medication. The cost of treatment with felbamate will be high.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • When felbamate is added to patients taking phenobarbital Phenobarbital it may cause increases in phenobarbital levels. When phenobarbital is added to patients taking felbamate, felbamate levels may decrease. The same effect may be seen with phenytoin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Ruehlmann D, Podell M, March P (2001)Treatment of partial seizures and seizure-like activity with felbamate in six dogs.JSAP42(8), 403-408PubMed.
  • McGee J H, Erikson D J, Galbreath C, Willigan D A, Sofia R D (1998)Acute, subchronic, and chronic toxicity studies with felbamate, 2-phenyl-1,3-propanediol dicarbamate.Toxicol Sci45(2), 225-232PubMed.
  • Podell M (1998)Antiepileptic drug therapy.Clin Tech Small Anim Pract13(3), 185-192PubMed.
  • Leppik I E (1994)Antiepileptic drugs in development: prospects for the near future.Epilepsia35Suppl 4, S29-40.
  • Romanyshyn L A, Wichmann J K, Kucharczyk N, Sofia R D (1993)Simultaneous determination of felbamate and three metabolites in rat and dog plasmas by high-performance liquid chromatography.J Chromatogr622(2), 229-234PubMed.
  • Adusumalli V E, Choi Y M, Romanyshyn L A, Sparadoski R E Jr, Wichmann J K, Wong K K, Kucharczyk N, Sofia R D (1993)Isolation and identification of 3-carbamoyloxy-2-phenylpropionic acid as a major human urinary metabolite of felbamate.Drug Metab Dispos21(4), 710-716PubMed.
  • Adusumalli V E, Gilchrist J R, Wichmann J K, Kucharczyk N, Sofia R D (1992)Pharmacokinetics of felbamate in pediatric and adult beagle dogs.Epilepsia33(5), 955-960PubMed.
  • Clark L A, Wichmann J K, Kucharczyk N, Sofia R D (1992)Determination of the anticonvulsant felbamate in beagle dog plasma by high-performance liquid chromatography.J Chromatogr573(1), 113-119PubMed.
  • Yang J T, Morris M, Wong K K, Kucharczyk N, Sofia R D (1992)Felbamate metabolism in pediatric and adult beagle dogs.Drug Metab Dispos20(1), 84-88PubMed.
  • Yang J T, Adusumalli V E, Wong K K, Kucharczyk N, Sofia R D (1991)Felbamate metabolism in the rat, rabbit, and dog.Drug Metab Dispos19(6), 1126-1134PubMed.
  • Adusumalli V E, Yang J T, Wong K K, Kucharczyk N, Sofia R D (1991)Felbamate pharmacokinetics in the rat, rabbit, and dog.Drug Metab Dispos19(6), 1116-1125PubMed.

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