Canis ISSN: 2398-2942

Esmolol

Contributor(s): Vetstream Ltd

Introduction

Class of drug

  • Ultra short-acting beta blocker.

Uses

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Indications

  • Treatment of supraventicular tachycardia:

Administration

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Precautions

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Interactions

with other drugs

Sympathomimetics

Anaesthetic agents, phenothiazines, antihypertensives, diazepam, diuretics and antiarrhythmics

  • Enhance hypotensive effect.

Calcium channel blockers

  • Diltiazem Diltiazem and verapamil Verapamil increase risk of bradycardia, severe hypotension, heart failure and AV block.

Digoxin

  • Bradycardia increased by concurrent administration.

Thyroid hormones

  • Enhance metabolism of esmolol thus reduce effect.
  • Dose of esmolol should be decreased when initiating carbimazole Carbimazole therapy.

Cimetidine

  • May decrease metabolism of esmolol.

Muscle relaxants

  • Esmolol enhances effects of suxamethonium Suxamethonium , tubocurarine.

Phenobarbitone and phenytoin

  • May increase rate of metabolism of esmolol by hepatic enzyme induction.

Lidocaine

  • Reduces lidocaine Lidocaine clearance therefore increases risk of lidocaine toxicity.

Theophylline

  • May block bronchodilatory effects of theophylline Theophylline.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.

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