Canis ISSN: 2398-2942

Epirubicin

Synonym(s): Pharmacorubicin

Contributor(s): William Brewer Jr

Introduction

Name

  • Epirubicin (4'-Epi-doxorubicin).

Class of drug

  • Cytotoxic anthracycline antibiotic.

Description

Chemical name

  • (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione.

Molecular formula

  • C27H29NO11.

Storage requirements

  • After reconstitution the drug is stable for 24 hours at room temperature.
  • Protect from light.

Uses

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Indications

  • In the dog, the drug has only been assessed against lymphomas.
  • In man, epirubicin has demonstrated efficacy against human breast, ovarian, lung, lymphoma, soft tissue sarcomas, and acute non-lymphocytic leukemia.
  • It may be used alone or with other anti-neoplastic therapies Chemotherapy: general principles.

Administration

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Precautions

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Interactions

with other drugs

Heparin

  • Forms precipitate with Epirubicin.

with diagnostic tests

  • Dogs should be periodically monitored with ECGs and/or echocardiograms.
  • Complete CBC and platelet count should be monitored whenever therapy is given. If the neutrphil count drops below 3x10³/dl or if the platelet count drops below 150x10³/dl, treatment should be suspended. Once the counts have stabilized doxorubicin can then be restarted at the same dose.
  • If hematological toxicity occurs again, or if gastrointestinal toxicity is recurrent the dose should be reduced to 25 mg/m².

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Fischer D S, Knobf M Tet al(2003)The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 113-114.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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