Canis ISSN: 2398-2942

Dobutamine

Contributor(s): Sandra Minors, Sheilah Robertson

Introduction

Name

  • Dobutamine.

Class of drug

  • Synthetic cardioactive sympathomimetic amine.
  • Principally a beta-1 adrenoceptor agonist with lesser degrees of alpha-1 and beta-2 agonist effects.
  • Weaker beta-2 agonist than isoproterenol.
  • Much weaker alpha-1 agonist than norepinephrine (noradrenaline) or dopamine Dopamine.

Description

Chemical name

  • (+/-)-4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol.
  • (+/-)-4-[2-[[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl]pyrocatechol.

Molecular formula

  • C18H23NO3.

Storage requirements

  • Reconstituted IV solution is stable for 24 hours although a slight color change (pale pink) may occur during this period.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs


Beta-blockers, eg propranolol

  • Dobutamine may be ineffective if beta-blockers Propranolol have recently been given.
Nitroprusside and dopamine
  • A synergistic effect on the improvement of cardiac output has been recorded with nitroprusside Nitroprusside and low dose dopamine Dopamine
    Do not mix in the administration line with alkaline solutions (heparin, hydrocortisone, sodium succinate, cefazolin, penicillin).

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Other sources of information

  • Small Animal Formulary.Bryn Tennant (1999) 3rd edn. Cheltenham: BSAVA.
  • Veterinary Emergency and Critical Care Manual.Karol A Mathews (1996) Lifelearn Inc.
  • Compendium of Pharmaceuticals and Specialities.13th Ed (1995), Ed in Chief Carmen M E Krogh.
  • Current Cardiovascular Drugs.(1994) WH Frishman, C T Dollery & J M Cruickshank. Current Medicine.
  • Heart Disease.A Textbook of Cardiovascular Medicine.(1992) Ed Eugene Braunwald. W B Saunders, Philadelphia.

ADDED