ISSN 2398-2942      

Dirlotapide

icanis

Synonym(s): Slentrol


Introduction

Name

  • Dirlotapide.

Class of drug

  • Microsomal triglyceride transfer protein inhibitor.

Description

Chemical name

  • (S)-N-(2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl)-1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1 H-indole-2-carboxamide.

Molecular formula

  • C40H33F3N4O3

Molecular weight

  • 674.73

Physical properties

  • Colorless to pale yellow oral solution.

Storage requirements

  • Store at room temperature 15-30°C (59-86°F).
  • Light sensitive.

Uses

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Indications

  • Indicated for the management of obesity Obesity in dogs. To be used as part of an overall weight management program, which also includes appropriate dietary changes and exercise.

Administration

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Precautions

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Interactions

with other drugs

  • Monitor drug interactions closely.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Gossellin J, McKelvie J, Sherington J et al (2007) An evaluation of dirlotapide to reduce body weight of client-owned dogs in two placebo-controlled clinical studies in Europe. J Vet Pharmacol Ther 30 (Suppl 1), 73-80 PubMed.
  • Merritt D A, Bessire A J, Vaz A D et al (2007) Absorption, distribution, metabolism, and excretion of dirlotapide in the dog. J Vet Pharmacol Ther 30 (Suppl 1), 17-23 PubMed.
  • Wren J A, Gossellin J & Sunderland S J (2007) Dirlotapide: a review of its properties and role in the management of obesity in dogs. J Vet Pharmacol Ther 30 (Suppl 1), 11-16 PubMed.
  • Wren J A, Ramudo A A, Campbell S L et al (2007) Efficacy and safety of dirlotapide in the management of obese dogs evaluated in two placebo-controlled, masked clinical studies in North America. J Vet Pharmacol Ther 30 (Suppl 1), 81-89 PubMed.

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