Canis ISSN: 2398-2942

Diphenhydramine

Contributor(s): Rosanna Marsella

Introduction

Name

  • Diphenhydramine.

Class of drug

  • Ethanolamine antihistamine.

Description

Chemical name

  • 2-diphenylmethoxy-N,N-dimethylethylethanamine.

Molecular formula

  • C17H21NO.

Physical properties

  • Powder that darkens with light exposure.
  • Bitter tasting.

Storage requirements

  • Room temperature.

Uses

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Indications

  • A component of some cough suppressants and is used in the management of coughing.
  • Reduces pruritus and vomiting (antihistaminic (H1) effects); effective in preventing motion sickness.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • CNS depressant drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Hofmeister E H & Egger C M (2005)Evaluation of diphenhydramine as a sedative for dogs.JAVMA226(7), 1092-1904.
  • Scott D W & Miller W H Jr (1993)Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus.J S Afr Vet Assoc64(1), 52-56.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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