Canis ISSN: 2398-2942

Diltiazem

Introduction

Name

  • Diltiazem.

Class of drug

  • Class IV antidysrhythmic agent.
  • Calcium channel blocker.

Uses

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Indications



Primary uses
Other conditions
  • Management of hypertension Hypertension.
  • To limit CNS damage following trauma.
Miscellaneous
  • Preferred to verapamil by many because it has effective antiarrhythmic properties with minimal negative inotropy.
  • Calcium channel blockers are preferred to propranolol for the management of feline hypertrophic cardiomyopathy by some authors because they improve myocardial relaxation, increases ventricular filling and dilate coronary vasculature.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs



Beta-adrenergic blockers, eg propranolol
  • If administered concurrently with propranolol Propranolol there may be additive negative inotropic and chronotropic effects.
Calcium salts, Vitamin DDigoxin, digitoxin
  • Plasma concentrations increased by diltiazem Digoxin Digitoxin.
  • Monitoring of digoxin serum levels is recommended.
Cimetidine
  • Cimetidine Cimetidine inhibits the metabolism of diltiazem thereby increasing plasma concentrations.
Theophylline
  • Diltiazem enhances the effect, which may lead to toxicity Theophylline.
Protein bound agents, eg warfarin
  • Diltiazem may displace warfarin Warfarin.
Vincristine
  • Diltiazem may increase intracellular levels by inhibiting the drug's outflow from the cell Vincristine.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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