Canis ISSN: 2398-2942

Dexmedetomidine (oromucosal gel)

Synonym(s): Sileo®; Dextrorotatory enantiomer of medetomidine; S-enantiomer of medetomidine

Contributor(s): Jo Murrell

Introduction

Name

  • Dexmedetomidine hydrochloride.

Class of drug

  • Alpha2 adrenergic agonist.

Description

Chemical name

  • [+]4-[1-[2,3-dimethylphenyl]-ethyl]-1H-imidazole monohydrochloride.

Molecular formula

  • C13H16N2.HCl

Molecular weight

  • 236.7

Physical properties

  • White or almost white powder that is freely soluble in water and has a pKa of 7.1. Partition coefficient in octanol: water at pH 7.4 is 2.89.
  • Supplied as an oromucosal gel formulation of dexmedetomidine hydrochloride provided in a 3 ml syringe at a concentration of 0.1 mg/ml. It has the appearance of a translucent green gel. It is designed for administration to dogs by their owners.

Storage requirements

  • May be stored for 48 hours after withdrawal of the first dose.
  • Keep the syringe in the carton to protect from light.
  • Do not freeze.

Uses

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Indications

  • Used for:

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Sedation may occur when Sileo® is administered is in combination with other drugs that cause CNS depression.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information


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