Canis ISSN: 2398-2942

Dexamethasone

Introduction

Name

  • Dexamethasone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (11-beta,16-alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H29FO5.

Physical properties

  • Colorless, sterile, aqueous solution.
  • Tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • High-dose therapy in conditions where water retention would be a disadvantage.
  • Anti-inflammatory potency 7.5 x >prednisolone.
  • Not suitable for alternate day use because of long duration of action.
  • Anti-inflammatory drug.
  • Assessment of adrenal function in suspect cases of hyperadrenocorticism Hyperadrenocorticism (dexamethasone suppression test) Low-dose dexamethasone suppression test.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Amphotericin B or potassium-depleting diuretics (furosemide, thiazides)
Insulin
  • May antagonize effects of insulin Insulin.
Phenobarbitone or phenytoinNon-steroidal inflammatory drugs
  • Increased risk of gastrointestinal ulceration if used concurrently.

with diagnostic tests



Urine glucose levels
  • May be increased.
T3 and T4
  • May decrease values.
Liver
  • Elevated liver enzymes.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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