Canis ISSN: 2398-2942

Deracoxib

Contributor(s): Jo Murrell

Introduction

Name

  • Deracoxib.

Class of drug

  • COX-2 inhibitor (although as with most COX-2 inhibitors, high doses can cause COX-1 inhibition).

Description

Chemical name

  • 4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole1-yl]benzenesulfonamide.

Molecular formula

  • C17H14F3N3O3S

Storage requirements

  • Keep put of reach of children.

Uses

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Indications

  • Treatment of chronic pain and lameness associated with osteoarthritis Arthritis: osteoarthritis in dogs.
  • Relief of pain and inflammation associated with orthopedic surgery in dogs.
  • Deracoxib is not licensed for administration to cats.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Do not use together with non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, medicines commonly used in the treatment of pain, inflammation and allergies. Dogs receiving ACE inhibitors and/or diuretics concurrently with deracoxib should be monitored carefully for signs of hypotension that will increase the risk of renal side effects.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Case J B, Fick J L, Rooney M B (2010)Proximal duodenal perforation in three dogs following deracoxib administration.JAAHA46, 255-258PubMed.
  • Gordon-Evans W J, Dunning D, Johnson A L, Knap K E (2010)Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy.Vet Comp Ortho Traumatol5,332-335PubMed.
  • Ryan W G, Carithers D, Moldave K, Bell M (2010)Field comparison of canine NSAIDS firocoxib and deracoxib.J Appl Res Vet Med8, 114-123.
  • Roberts E S, Van Lare K A, Marable B R, Salminen W F (2009)Safety and tolerability of 3- week and 6-month dosing of Deramaxx (deracoxib) chewable tablets in dogs.J Vet Pharmacol Therap32, 329-337PubMed.
  • Sennello K & Leib M S (2006)Effects of deracoxib or buffered aspirin on the gastric mucosa of healthy dogs.JVIM20, 1291-1296PubMed.
  • Lascelles B D, Blikslager A T, Fox S M, Reece D (2005)Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase -2 inhibitor: 29 cases (2002-2003).JAVMA227, 1112-1117PubMed.

Other sources of information


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