Canis ISSN: 2398-2942

Cyproheptadine

Contributor(s): Rosanna Marsella

Introduction

Name

  • Cyproheptadine hydrochloride.

Class of drug

  • Antihistamine, seratonin antagonist.

Description

Physical properties

  • White powder - water soluble.

Storage requirements

  • At room temperature.

Uses

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Indications

  • Symptomatic relief of allergic skin disease.
  • Appetite stimulation in cats.
  • Aid in management of feline asthma.
  • Adjunctive therapy in treatment of hyperadrenocorticism Hyperadrenocorticism.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Additive CNS effects with barbiturates.
  • Monoamine oxidase inhibitors intensify anticholinergic effects.

with diagnostic tests

  • Increases serum amylase concentrations inasocitation with thyrotropin releasing hormone.
  • Decreases reaction to intradermal allergen testing.
    Discontinue for 7-10 days before performing test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Garcia G, DeMora F, Ferrer L & Puigdemont A (1997)Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells.Am J Vet Res58(3), 293-297.
  • Peterson M E & Kintzer P P (1994)Medical treatment of pituitary-dependent hyperadrenocorticism in dogs.Semin Vet Med Surg - Sm Anim9(3), 127-131.
  • Scott D W, Miller W H Jr & Cayatte S M (1992)Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs - result of double-blinded, placebo-controlled study.Cornell Vet82(3), 247-251.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • PlumbVeterinary Drug handbook3 edn. pp 190-192.

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