Canis ISSN: 2398-2942

Cyproheptadine

Contributor(s): Rosanna Marsella, Vetstream Ltd

Introduction

Name

  • Cyproheptadine hydrochloride.

Class of drug

  • Antihistamine, seratonin antagonist.

Description

Physical properties

  • White powder - water soluble.

Storage requirements

  • At room temperature.

Uses

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Indications

  • Symptomatic relief of allergic skin disease.
  • Appetite stimulation in cats.
  • Aid in management of feline asthma.
  • Adjunctive therapy in treatment of hyperadrenocorticism Hyperadrenocorticism.

Administration

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Precautions

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Interactions

with other drugs

  • Additive CNS effects with barbiturates.
  • Monoamine oxidase inhibitors intensify anticholinergic effects.

with diagnostic tests

  • Increases serum amylase concentrations inasocitation with thyrotropin releasing hormone.
  • Decreases reaction to intradermal allergen testing.
    Discontinue for 7-10 days before performing test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • García G, DeMora F, Ferrer L et al (1997) Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells. Am J Vet Res 58 (3), 293-297 PubMed.
  • Peterson M E & Kintzer P P (1994) Medical treatment of pituitary-dependent hyperadrenocorticism in dogs. Semin Vet Med Surg - Sm Anim (3), 127-131 PubMed.
  • Scott D W, Miller W H Jr., Decker G A et al (1992) Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: result of double-blinded, placebo-controlled study. Cornell Vet 82 (3), 247-251 VetMedResource.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb Veterinary Drug handbook 3rd edn. pp 190-192.

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