Canis ISSN: 2398-2942

Clomipramine hydrochloride

Synonym(s): Clomipramine

Contributor(s): Vetstream Ltd

Introduction

Name

  • Clomipramine.

Class of drug

  • Tricyclic antidepressant.

Description

Chemical name

  • 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine; 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine.

Molecular formula

  • C19H23ClN2.

Storage requirements

  • Store below 30°C.
  • Keep dry.

Uses

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Indications

  • May be useful in the management of obsessive-compulsive canine behaviours Stereotype behavior such as tail chasing, fly biting, flank sucking, licking associated with lick granulomas Skin: acral lick granuloma.
  • Separation anxiety in dogs.
  • Elimination problems in cats.
  • It should be used in combination with behavioural therapy for separation related disorders manifested by destruction and inappropriate urination and defecation.

Administration

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Precautions

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Interactions

with other drugs

Anesthetics, anti-arrhythmics

  • Concurrent use increases the risk of arrhythmias.

Anti-epileptics

  • Clomipramine antagonizes the effects of anti-epileptic drugs.

Sedatives

  • Enhances the effects of sedative drugs.
  • Do not use in conjunction with monoamine oxidase inhibitors.
  • Certain drugs auch as phenytoin may have increased plasma levels if used simultaneously.
  • May potentiate the effects of quinidine, anticholinergic drugs, eg atropine, other drugs acting on the CNS and sympathomimetics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Landsberg G M (2001) Clomipramine--beyond separation anxiety. JAAHA 37 (4), 313-318 PubMed.
  • Horwitz D F (2000) Diagnosis and treatment of canine separation anxiety and the use of clomipramine hydrochloride (clomicalm). JAAHA 36 (2), 107-109 PubMed.

Other sources of information

  • Based on BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA. 

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