Canis ISSN: 2398-2942

Clomipramine hydrochloride

Synonym(s): Clomipramine

Introduction

Name

  • Clomipramine.

Class of drug

  • Tricyclic antidepressant.

Description

Chemical name

  • 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine; 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine.

Molecular formula

  • C19H23ClN2.

Storage requirements

  • Store below 30°C.
  • Keep dry.

Uses

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Indications

  • May be useful in the management of obsessive-compulsive canine behaviours Stereotype behavior such as tail chasing, fly biting, flank sucking, licking associated with lick granulomas Skin: acral lick granuloma.
  • Separation anxiety in dogs.
  • Elimination problems in cats.
  • It should be used in combination with behavioural therapy for separation related disorders manifested by destruction and inappropriate urination and defecation.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Anesthetics, anti-arrhythmics
  • Concurrent use increases the risk of arrhythmias.
Anti-epileptics
  • Clomipramine antagonizes the effects of anti-epileptic drugs.
Sedatives
  • Enhances the effects of sedative drugs.
  • Do not use in conjunction with monoamine oxidase inhibitors.
  • Certain drugs auch as phenytoin may have increased plasma levels if used simultaneously.
  • May potentiate the effects of quinidine, anticholinergic drugs, eg atropine, other drugs acting on the CNS and sympathomimetics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Landsberg G M (2001)Clomipramine - beyond separation anxiety.JAAHA37(4), 313-318.
  • Horwitz D F (2000)Diagnosis and treatment of canine separation anxiety and the use of clomipramine hydrochloride (clomicalm).JAAHA36(2), 107-109.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7.

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