Canis ISSN: 2398-2942

Cisapride

Synonym(s): Prepulsid

Contributor(s): Lauren Trepanier

Introduction

Name

  • Cisapride.

Class of drug

  • Prokinetic agent.

Description

Chemical name

  • cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidninyl]-2-methoxybenzamide;cis-4-amino-5-chloro-N-[1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide.

Molecular formula

  • C23H29CLFN3O4.

Storage requirements

  • Store at room temperature.
  • Keep out of light and keep dry.

Uses

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Indications

  • Management of:
    Cisapride has been withdrawn for use in humans in both the UK (July 2000) and USA. This decision follows reports of rare, but serious, ventricular arrhythmias (some fatal) suspected to be caused by the drug

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Opioid analgesics and antimuscarinics, eg atropine Atropine may antagonize cisapride's effects.
  • Fatal arrhythmia may be seen in conjunction with:
    • Erythromycin, clarythromycin, troleandomycin.
    • Itraconazole, ketoconazole, fluconazole and miconazole.
  • Increases bioavailability of cyclosporine.
  • Increases absorption of aspirin, acetaminophen, diazepam, ethanol.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Le Grange S N, Boothe D M, Herndon Set al(1997)Pharmacokinetics and suggested oral dosing regime of cisapride - a study in healthy cats.JAAHA33, 517-523.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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