Canis ISSN: 2398-2942

Cimetidine

Contributor(s): Lauren Trepanier

Introduction

Name

  • Cimetidine.

Class of drug

  • H2-antihistamine.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs



Drugs affected by cimetidine (increased plasma levels)
Sucralfate
  • Sucralfate may reduce bioavailability of H2 antagonists.
  • While there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate Sucralfate at least 30 minutes before cimetidine.
Antacids, digoxin, ketoconazole, metoclopropamide

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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