Canis ISSN: 2398-2942

Chlorphenamine

Synonym(s): Chlorpheniramine

Contributor(s): Rosanna Marsella

Introduction

Name

  • Chlorphenamine.

Class of drug

  • H1 antihistamine.

Description

Chemical name

  • Gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine.
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine.

Molecular formula

  • C16H19ClN2.

Physical properties

  • Oily liquid.
  • 1 g soluble in 4 ml water.

Storage requirements

  • Injectable preparations should be stored in light-resistant containers

Uses

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Indications

  • Allergies.
  • Anaphylactic reactions.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • CNS depressant drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Paterson S (1995)Additive benefits of EFA's in dogs with atopic dermatitis after partial response to antihistamine therapy.JSAP36(9), 389-394.
  • Scott D W & Miller W H Jr (1990)Nonsteroidal management of canine pruritis - chlorpheniramine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage.Cornell Vet80(4), 381-387.
  • Misawa M, Takenouchi K, Sato M & Yanaura S (1987)The effects of chlorpheniramine and antiallergic drugs on Ascaris suum antigen-induced active cutaneous anaphylaxis in dogs.Jpn J Pharmacol44(1), 101-104.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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