Canis ISSN: 2398-2942

Chlorambucil

Contributor(s): William Brewer Jr

Introduction

Name

  • Chlorambucil.

Class of drug

  • Antineoplastic cytotoxic immunosuppressive alkylating agent.

Description

Chemical name

  • 4-[bis(2-chloroethyl)amino]benzenebutanoic acid.
  • 4-[p-[bis(2-chloroethyl)amino]phenyl]butryic acid.

Molecular formula

  • C14H19Cl2NO2.

Physical properties

  • 2 mg tablets.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Phenobarbitone Phenobarbital - increases cytotoxic effects of chlorambucil.
  • Prednisolone Prednisolone - synergistic effect in management of lymphoid neoplasia.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Fraizier D L & Hahn K A (1995)Commonly Used Drugs.In: Hahn K A & Richardson R C (eds)Cancer Chemotherapy A Veterinary Handbook. Philadelphia, PA. Williams & Wilkins. pp 90.

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