Canis ISSN: 2398-2942

Carprofen

Contributor(s): Cheryl Blaze, Kyle Braund

Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Analgesic activity enhanced if used pre-emptively.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.
Nephrotoxic agents
  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Further Reading

Publications

Refereed papers

  • Raekallio M R, Hielm-Bjorkman A K, Kejonen J, Salonen H M & Sankari S M (2006)Evaluation of adverse effects of long-term orally administered carprofen in dogs.JAVMA228, 876-880PubMed.
  • Mellor P J, Roulois A J A, Day M J, Blacklaws B A, Knivett S J & Herrtage M E (2005)Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: supected adverse reaction to carprofen.JSAP46, 237-242PubMed.
  • Tomlinson J & Blikslager A (2003)Role of non-steroidal anti-inflammatory drugs in gastrointestinal tract injury and repair.JAVMA222(7), 946-951.PubMed
  • Halter F, Tarnawski A S, Schmassmann A & Peskar B M (2001)Cyclooxygenase 2 - implications on maintenance of gastic mucosal integrity and ulcer healing: controversial issues and perspectives.Gut49(30), 443- 453.PubMed
  • Firth A M & Haldane S L (1999)Development of a scale to evaluate post operative pain in dogs.JAVMA214(5), 651-659.PubMed
  • Isaacs J P (1999)Caprofen.Comp Contin Educ Pract Vet21(3) , 246-248.
  • Lascelles B D, Cripps P J, Jones A & Waterman-Pearson A E (1998)Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy.Vet Surg27(6), 568-582.PubMed
  • Balmer T & Curwen A (1997)Analgesia in cats.Vet Rec140,435.
  • Mizuno H, Sakamoto C, Matsuda Ket al(1997)Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice.Gastroenterol112,387-397.PubMed

Other sources of information

  • Pfizer, Inc (2002)Five-year safety profile for Rimadyl (carprofen).
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • David A & Simon A (1999)Use of Rimadyl in cats.Vet RecDec 18/25,743. (Letter)

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