Canis ISSN: 2398-2942

Carprofen

Contributor(s): Cheryl Blaze, Kyle Braund

Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Analgesic activity enhanced if used pre-emptively.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.

Nephrotoxic agents

  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMed Resource.
  • Raekallio M R, Hielm-Bjorkman A K, Kejonen J, Salonen H M & Sankari S M (2006) Evaluation of adverse effects of long-term orally administered carprofen in dogs. JAVMA 228, 876-880 PubMed.
  • Mellor P J, Roulois A J A, Day M J, Blacklaws B A, Knivett S J & Herrtage M E (2005)Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: supected adverse reaction to carprofenJSAP 46, 237-242 PubMed.
  • Tomlinson J & Blikslager A (2003) Role of non-steroidal anti-inflammatory drugs in gastrointestinal tract injury and repair. JAVMA 222(7), 946-951 PubMed.
  • Halter F, Tarnawski A S, Schmassmann A & Peskar B M (2001) Cyclooxygenase 2 - implications on maintenance of gastic mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49(30), 443- 453 PubMed.
  • Firth A M & Haldane S L (1999) Development of a scale to evaluate post operative pain in dogs. JAVMA 214(5), 651-659 PubMed.
  • Isaacs J P (1999) Caprofen. Comp Contin Educ Pract Vet 21(3) , 246-248.
  • Lascelles B D, Cripps P J, Jones A & Waterman-Pearson A E (1998) Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 27(6), 568-58. PubMed.
  • Balmer T & Curwen A (1997) Analgesia in cats. Vet Rec 140,435.
  • Mizuno H, Sakamoto C, Matsuda K et al(1997)I nduction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterol 112,387-397 PubMed.

Other sources of information

  • Pfizer, Inc (2002) Five-year safety profile for Rimadyl (carprofen).
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • David A & Simon A (1999) Use of Rimadyl in cats. Vet Rec Dec 18/25,743. (Letter)

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