ISSN 2398-2942      

Carprofen

icanis
Contributor(s):

Cheryl Blaze

Kyle Braund


Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Analgesic activity enhanced if used pre-emptively.

Administration

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.

Nephrotoxic agents

  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Raekallio M R, Hielm-Björkman A K, Kejonen J et al (2006) Evaluation of adverse effects of long-term orally administered carprofen in dogs. JAVMA 228 (6), 876-880 PubMed.
  • Mellor P J, Roulois A J A, Day M J et al (2005) Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: supected adverse reaction to carprofen. JSAP 46 (5), 237-242 PubMed.
  • Tomlinson J & Blikslager A (2003) Role of nonsteroidal anti-inflammatory drugs in gastrointestinal tract injury and repair. JAVMA 222 (7), 946-951 PubMed.
  • Halter F, Tarnawski A S, Schmassmann A et al (2001) Cyclooxygenase 2 - implications on maintenance of gastic mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49 (3), 443-453 PubMed.
  • Firth A M & Haldane S L (1999) Development of a scale to evaluate postoperative pain in dogs. JAVMA 214 (5), 651-659 PubMed.
  • Isaacs J P (1999) Carprofen. Comp Contin Educ Pract Vet 21 (3), 246-248 VetMedResource.
  • Lascelles B D, Cripps P J, Jones A et al (1998) Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 27 (6), 568-582 PubMed.
  • Balmer T & Curwen A (1997) Analgesia in cats. Vet Rec 140 (16), 435 PubMed.
  • Mizuno H, Sakamoto C, Matsuda K et al (1997) Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterol 112 (2), 387-397 PubMed.

Other sources of information

  • Pfizer, Inc (2002) Five-year safety profile for Rimadyl (carprofen).
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • David A & Simon A (1999) Use of Rimadyl in cats. Vet Rec Dec 18/25, 743. (Letter)
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