Canis ISSN: 2398-2942

Carboplatin

Synonym(s): Paraplatin

Contributor(s): William Brewer Jr, Vetstream Ltd

Introduction

Name

  • Carboplatin.

Class of drug

  • Platinum compound antineoplastic agent.
  • Alkylating type agent.

Description

Chemical name

  • (SP-4-2)-Diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']platinum; 1, 1-cyclobutanedicarboxylic acid platinum complex.

Molecular formula

  • C6H12N2O4Pt.

Physical properties

  • White crystals.
  • Soluble in water.

Storage requirements

  • Room temperature and protected from light.
  • Reconstituted solutions at 1 mg/ml are stable for 24 hours at room temperature and 5 days in refrigerator.

Uses

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Indications

  • Used against various carcinomas and sarcomas.
  • Increases the survival time when used as an adjunct to amputation in dogs with appendicular osteosarcoma.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Rassnick et al (2001) Use of carboplatin for treatment of dogs with malignant melanoma -27 cases (1989-2000). JAVMA 218(9), 1444-1448.
  • Fox L E et al(2000) Carboplatin. J Am Anim Hosp Assoc 36, (1) 13-4.

Other sources of information

  • Fischer D S, Knobf M T et al(2003) The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 234-236.
  • Plumb D C (2002) Veterinary Drug Handbook. 4th edn. Ames, IA: Iowa State Press. pp 132-134.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Theon A (1997) Intratumoral Chemotherapy in Small Animals. In: Proceedings of the 15th Annual Veterinary Medical Forum American College of Veterinary Internal Medicine. pp 180-181.

 


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