Canis ISSN: 2398-2942

Buprenorphine

Contributor(s): John Dodam, Sheilah Robertson

Introduction

Name

  • Buprenorphine.

Class of drug

  • Long-acting partial opioid antagonist-agonist.

Description

Chemical name

  • [5-alpha,7-alpha(S)]-17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol.
  • 21-cyclopropyl-7-alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine.

Molecular formula

  • C29H41NO4.

Physical properties

  • Colourless, aqueous solution.

Storage requirements

  • <25°C.
  • Protect from light.
  • Discard any solution remaining in opened vial after dose withdrawn.

Uses

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Indications

  • May be mixed with acepromazine Acepromazine maleate to produce neuroleptanalgesia Therapeutics: nervous system for minor procedures or pre-operative medication.
  • Used to relieve moderate pain.
  • Sedative and euphoric effects less marked than those produced by morphine.
  • Can be used to prolong analgesia in patients with severe pain where the pain has been controlled with pure opiate agonists Analgesia: opioid.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Opioid analgesics

  • Do not use simultaneously with these as it is a partial agonist and will antagonize the effects of full agonists (morphine Morphine , pethidine Pethidine ).
  • May potentiate sedative and ventilatory depressant effects of other CNS depressants.

Adverse Reactions

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Further Reading

Publications

Referred papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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