Canis ISSN: 2398-2942

Betamethasone

Contributor(s): Vetstream Ltd

Introduction

Name

  • Betamethasone.

Class of drug

  • Glucocorticoid.

Description

Chemical name

  • (11-beta,16-beta)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H29FO5.

Physical properties

  • Sterile, white aqueous suspension.
  • White tablets.
  • Slightly viscous, yellow oily suspension.

Storage requirements

  • <25°C.
  • Do not store in fridge or freezer.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Anti-inflammatory - potency 8.75 times greater than prednisolone.
  • May have role in management of shock Shock.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Anti-epileptic drugs (phenobarbitone, phenytoin and primidone)

  • Metabolism of corticosteroids may be accelerated.

Insulin

  • Glucocorticoids may antagonize the effect of insulin.

Acetazolamide, amphotericin and potassium depleting diuretics (frusemide, thiazides)Non-steroidal anti-inflammatory drugs

  • Increased risk of gastrointestinal ulceration if NSAIDs used concurrently.
  • Concurrent use of corticosteroids increases risk of hypokalemia.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Ramsey I (2017) Small Animal Formulary. 9th edn. 

ADDED