Canis ISSN: 2398-2942

Atropine

Contributor(s): Stephen Barr, Vetstream Ltd

Introduction

Name

  • Atropine.

Class of drug

  • Parasympatholytic agent.

Description

Chemical name

  • Endo-(+/-)-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester.
  • 1-alphaH,5-alphaH-tropan-3-alpha-ol(+/-)-tropate (ester).

Molecular formula

  • C17H23NO3.

Physical properties

  • Clear, sterile solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Drugs which may enhance the activity of atropine

  • Antihistamines.
  • Procainamide.
  • Quinidine.
  • Pethidine.
  • Benzodiazepines.
  • Phenothiazines.

The adverse effects of atropine may be potentiated by

  • Primidone.
  • Disopyramide.
  • Corticosteroids (prolonged use may increase intra-ocular pressure).

Drugs enhanced by atropine

  • Thiazide diuretics.
  • Sympathomimetics.

Drugs antagonized by atropine

  • Metoclopramide.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED