Canis ISSN: 2398-2942

Atropine

Contributor(s): Stephen Barr

Introduction

Name

  • Atropine.

Class of drug

  • Parasympatholytic agent.

Description

Chemical name

  • Endo-(+/-)-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester.
  • 1-alphaH,5-alphaH-tropan-3-alpha-ol(+/-)-tropate (ester).

Molecular formula

  • C17H23NO3.

Physical properties

  • Clear, sterile solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs



Drugs which may enhance the activity of atropine
  • Antihistamines.
  • Procainamide.
  • Quinidine.
  • Pethidine.
  • Benzodiazepines.
  • Phenothiazines.
The adverse effects of atropine may be potentiated by
  • Primidone.
  • Disopyramide.
  • Corticosteroids (prolonged use may increase intra-ocular pressure).
Drugs enhanced by atropine
  • Thiazide diuretics.
  • Sympathomimetics.
Drugs antagonized by atropine
  • Metoclopramide.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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