Canis ISSN: 2398-2942

Atenolol

Introduction

Name

  • Atenolol.

Class of drug

  • Beta-1 adrenoceptor antagonist (beta blocker).

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs



Sympathomimetics, eg epinephrine, phenylpropanolamine, terbutaline
  • May have their beta-effects blocked by atenolol.
  • Thus, the unopposed alpha effects may result in severe hypertension and a decreased heart rate.
Anesthetic agents (those that depress myocardial activity), phenothiazines, antihypertensive drugs, eg hydralazine, prazosin, diazepam, diuretics and other anti-arrhythmics
  • Hypotensive effect of atenolol enhanced.
Calcium channel blockers, eg diltiazem, verapimil
  • There is an increased risk of bradycardia, severe hypotension, heart failure and AV block if used concurrently with atenolol.
Digoxin
  • Concurrent administration potentiates bradycardia.
Thyroid hormones
  • Accelerate metabolism of atenolol thus reducing its effect.
Carbimazole
  • Atenolol dose may need to be decreased when initiating therapy with carbimazole.
Aluminium hydroxide
  • Oral preparations reduce atenolol absorption.
Cimetidine
  • May decrease the metabolism of atenolol, thereby increasing its blood levels.
Muscle relaxants, eg tubocurarine, suxamethonium
  • Effects enhanced by atenolol.
Phenobarbitone, rifampin or phenytoin
  • Hepatic enzyme induction by these drugs may increase the rate of metabolism of atenolol.
Insulin
  • May prolong the hypoglycemic effects of insulin therapy.
Lignocaine
  • Increased rate of lignocaine toxicity when administered with atenolol due to a reduction in lignocaine clearance.
Theophylline
  • The bronchodilatory effects may be blocked by atenolol.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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