Canis ISSN: 2398-2942

Ampicillin

Introduction

Name

  • Ampicillin.

Class of drug

  • Aminopenicillin.

Description

Chemical name

  • [2S-[2-alpha,5-alpha,6-beta(S*)]]-6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H19N3O4S.

Physical properties

  • Sterile, non-aqueous suspension.
  • White tablets.
  • Clear yellow aqueous solution.
  • Red and gray capsules.

Storage requirements

  • <25°C.
  • Store tablets in a dry environment.
  • Do not store in freezer.
  • Can be stored in fridge (between 2-8°C).

Uses

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Indications

  • Ampicillin is an acid-stable, beta-lactamase-susceptible aminopenicillin active against many gram-positive and negative organisms, but not against those that produce penicillinases, egE. coliandStaphylococcus aureus.
  • The difficult gram negative organisms (egPseudomonasspp andKlebsiellaspp) are usually resistant.
  • Most obligate anaerobes are susceptible.
  • Ampicillin is excreted well in bile and urine.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Avoid the concurrent use of ampicillin with bacteriostatic antibiotics, eg tetracycline Tetracycline , erythromycin Erythromycin , chloramphenicol Chloramphenicol.
  • Probenecid will decrease the renal tubular secretion of penicillin antibiotics and thus prolong their blood levels.
Aminoglycosides
  • Do not mix in the same syringe as aminoglycosides.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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