Canis ISSN: 2398-2942

Amlodipine

Synonym(s): Amlodipine besylate; Istin; Norvasc

Contributor(s): Esther Bijsmans

Introduction

Name

  • Amlodipine besylate.

Class of drug

  • Third generation dihydropyridine.
  • Calcium-channel blocker.

Description

Chemical name

  • (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Molecular formula

  • C20H25ClN2O5

Molecular weight

  • 408.879 

Storage requirements

  • Store at room temperature (15-30°C). 
  • Store away from heat, moisture, and light. Do not store in the bathroom. Keep out of reach of children and away from pets.

Uses

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Indications

  • Primary hypertension.
  • Second hypertension (eg due to acute kidney injury AKI).
  • Can also be used in dogs with mitral regurgitation Atrioventricular valve dysplasia that are refractory to conventional heart failure therapy.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Referred papers

  • Recent references from VetMed Resource and PubMed.
  • Geigy C , Schweighauser A, Doherr M, Francey T (2011) Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate. JSAP 52 (7), 340-346 PubMed.
  • de Madron E, King J N, Strehlau G, & Valle White R (2011) Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: A retrospective study of 21 cases. Can Vet J 52 (11), 1219-1225 PubMed.
  • Atkins C E, Rausch W P, Gardner S Y, Defrancesco T C, Keene B W, Levine J F (2007) The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog. J Vet Pharmacol Ther 30 (5), 394-400 PubMed.
  • Ji Li, You Li, Wenting Zhang, Zhao Chen, Guorong Fan (2013) Glucose-²-CD interaction assisted ACN field-amplified sample stacking in CZE for determination of trace amlodipine in beagle dog plasma. Journal of Separation Science 36 (11), pp. 1817-1825 PubMed.
  • Creevy K E, Scuderi M A, Ellis A E (2013) Generalised peripheral oedema associated with amlodipine therapy in two dogs. JSAP 54 (11), 601-604PubMed.
  • Thomason J D, Fallaw T L, Carmichael K P et al(2009) Gingival hyperplasia associated with the administration of amlodipine to dogs with degenerative valvular disease (2004-2008). J Vet Intern Med 23 (1), 39-42 PubMed.
  • Stopher D A, Beresford A P, Macrae PV, Humphrey M J (1988) The metabolism and pharmacokinetics of amlodipine in humans and animals. J Cardiovasc Pharm 12 (7), S55-S59.

Other sources of information

  • Based on Small Animal Formulary. Ramsey I (2014) 8th edn. Cheltenham: BSAVA.

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