Canis ISSN: 2398-2942

Amitryptiline

Contributor(s): Rosanna Marsella

Introduction

Name

  • Amitryptiline.

Class of drug

  • Tricyclic antidepressant.

Description

Physical properties

  • Soluble in water and alcohol.
  • Bitter taste.

Uses

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Indications

  • Management of pruritus and psychogenic dermatoses where anxiety is a component.
  • Controlling urine marking in cats.
  • Management of feline lower urinary tract disorders.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Anaesthetics and anti-dysrhythmics
  • Increased risk of dysrhythmias.
Anti-epileptics
  • Antagonises the effects of anti-epileptics.
  • Cimetidine → reduces metabolism of amitriptyline → increased concentration of amitriptyline.
Sedatives
  • Increases sedative effect if used with other sedative drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Scott D W & Miller W H Jr (1993)Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus.J S Afr Vet Assoc64(1), 52-56.
  • Miller W H Jr, Scott D W & Wellington J R (1992)Nonsteroidal management of canine pruritus with amitriptyline.Cornell Vet82(1), 53-57.
  • Friehe H & Fontaine R (1978)Toxicology of amitriptylinoxide.Arzneimittelforschung28(10b), 1898-1907.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DVeterinary Drug handbook3 edn. pp 34-36.

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