Canis ISSN: 2398-2942

Aminophylline

Synonym(s): Theophylline-ethylenediamine, theophyllamine

Introduction

Name

  • Aminophylline.

Class of drug

  • Methylxanthine.

Description

Chemical name

  • 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compound + 1,2-ethanediamine (2:1).
  • Theophylline compound + ethylenediamine.

Molecular formula

  • C16H24N10O4.

Physical properties

  • Aminophylline is a mixture of theophylline and ethylenediamine, the latter increases the water solubility of theophylline.
  • 100 mg of aminophylline is equivalent to 79 mg of theophylline.

Uses

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Indications

  • To dilate bronchi.
  • Pulmonary edema.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

  • Do not mix aminophylline in a syringe with other drugs.
Beta-adrenergic blockers, eg propranolol
  • May antagonise each others effect.
Halothane
  • May increase incidence of cardiac dysrhythmias.
Ketamine
  • May increase incidence of seizures.
Phenytoin
  • Theophylline may decrease effect of phenytoin.
Pancuronium
  • Theophylline may decrease the effects of pancuronium.
Agents which may increase theophylline effect
  • Cimetidine.
  • Erythromycin.
  • Allopurinol.
  • Thiabendazole.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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