Canis ISSN: 2398-2942

Amikacin

Introduction

Name

  • Amikacin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Gentamicin-resistant infections Gentamicin.
  • Gram-negative infections.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Other nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B, cisplatin, frusemide, methoxyflurane. Increase monitoring and adjust dosages when these drugs must be used with amikacin.
  • Aminoglycosides may be inactivated by Beta-lactam antibiotics, eg penicillins, cephalosporins or heparin when mixedin vitro. This may present a problemin vivoin patients who have substantially diminished renal function.
  • The effect ofNon-depolarizing muscle relaxants, eg atracurium, pancuronium, tubocuramine, vecuronium may be enhanced by aminoglycosides.
  • Synergism may occur when aminoglycosides are used with Penicillins or cephalosporins (Streptococcus faecalis) or ticarcillin Ticarcillin (Pseudomonas aeruginosa Pseudomonas aeruginosa ).

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7.

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