Canis ISSN: 2398-2942

Allopurinol

Contributor(s): Lauren Trepanier, Vetstream Ltd

Introduction

Name

  • Allopurinol.

Class of drug

  • Xanthine oxidase inhibitor.

Uses

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Indications

  • Uric acid uroliths and hyperuricosuric calcium oxalate urolithiasis Urolithiasis prophylaxis to prevent recurrence.
  • Reperfusion injuries to decrease lipid peroxidation.
  • Evidence of its efficacy is lacking.

  • Induction and maintenance of remission in animals treated for leishmaniasis Canine leishmaniosis with meglumine antimonate Meglumine antimoniate.

Administration

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Precautions

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Interactions

with other drugs

  • Allopurinol inhibits the metabolism of azothioprine and enhances the risk of neutropenia. The combination should be avoided.
  • In Man may increase the effect of:

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cavaliero T, Arnold P, Mathis P et al (1999) Clinical, serologic and parasitologic follow-up after long-term allopurinol therapy of dogs naturally infected with Leishmania infantum. JVIM 13 (4), 330-334 PubMed.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7.

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