ISSN 2398-2942      

Alfentanil

icanis
Contributor(s):

John Dodam

Vetstream Ltd


Introduction

Name

  • BANM.

Class of drug

  • Analgesics (µ opiate agonist).

Description

Chemical name

  • Alfentanil hydrochloride.

Molecular formula

  • 4-anilinopipridine analogue.

Physical properties

  • Water soluble.
  • Lipid soluble.
  • pKa - 6.8.

Uses

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Indications

Analgesia/profound sedation

  • Either alone for very short procedures, eg radiotherapy.
  • Or used in conjunction with other anesthetics as part of a balanced anesthesia protocol.
  • Augments intra-operative analgesia.
  • Decreases amount of other anesthetics required.

Ophthalmic anesthesia

  • Improved reduction in intra-ocular pressure compared to fentanyl Fentanyl (parenteral) with similar cardiac stability.
    Potent respiratory depressant. Must have facilities for tracheal intubation Endotracheal intubation and IPPV.

Administration

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Precautions

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Interactions

with other drugs

  • Reduces MAC of halothane Halothane by almost 50%.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.
  • Clinical Anaesthetic Pharmacology. (1991) Eds: John W Dundee, R S J Clarke & William McCaughey. Pub Churchill Livingstone.
  • Martindale: The Extra Pharmacopoeia. The London Pharmaceutical Society. 31st Edn.
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