Canis ISSN: 2398-2942

Alfentanil

Contributor(s): John Dodam

Introduction

Name

  • BANM.

Class of drug

  • Analgesics (µ opiate agonist).

Description

Chemical name

  • Alfentanil hydrochloride.

Molecular formula

  • 4-anilinopipridine analogue.

Physical properties

  • Water soluble.
  • Lipid soluble.
  • pKa - 6.8.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Analgesia/profound sedation

  • Either alone for very short procedures, eg radiotherapy.
  • Or used in conjunction with other anesthetics as part of a balanced anesthesia protocol.
  • Augments intra-operative analgesia.
  • Decreases amount of other anesthetics required.

Ophthalmic anesthesia

  • Improved reduction in intra-ocular pressure compared to fentanyl Fentanyl (parenteral) with similar cardiac stability.
    Potent respiratory depressant. Must have facilities for tracheal intubation Endotracheal intubation and IPPV.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Reduces MAC of halothane Halothane by almost 50%.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Clinical Anaesthetic Pharmacology. (1991) Eds: John W Dundee, R S J Clarke & William McCaughey. Pub Churchill Livingstone.
  • Martindale: The Extra Pharmacopoeia. The London Pharmaceutical Society. 31st Edn.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7

ADDED