ISSN 2398-2942      

Aglepristone

icanis

Synonym(s): RU 534


Introduction

Name

  • Aglepristone.

Class of drug

  • Progesterone receptor antagonist.

Description

Chemical name

  • (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Molecular formula

  • C29H37NO2

Molecular weight

  • 431.60958

Physical properties

  • Clear yellow oily solution.

Storage requirements

  • Shelf life of 3 years.
  • Once opened must be used within 28 days and discarded if discoloration occurs.
  • As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
  • Protect the bottle from light.

Uses

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Indications

  • Induction of abortion up to 45 days after unintended mating in bitches Mesalliance.

Administration

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Precautions

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Interactions

with other drugs

  • Avoid use with ketoconazole Ketoconazole , itraconazole Itraconazole and erythromycin Erythromycin as interaction may occur.
  • May reduce the effect of glucocorticoid treatment.

with diagnostic tests

  • Hematological and biochemical changes (urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST) reported in up to 5% of dogs following injection Blood biochemistry: overview.

Precautions for the personnel handling the product

  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • Pregnant women should handle the product with extreme care.
  • Care should be taken by the veterinary surgeon when administering the product and the person restraining the treated dog to avoid self-injection.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Agaoglu A R, Schäfer-Somi S, Kaya D et al (2011) The intravaginal application of misoprostol improves induction of abortion with aglepristone. Theriogenology 76 (1), 74-82 PubMed.
  • Rigau T, Rodríguez-Gil J E, García F et al (2011) Partial foetal retention following aglepristone treatment in a bitch. Reprod Domest Anim 46 (4), 738-741 PubMed.
  • Pettersson C H, Tidholm A (2009) Safety and efficacy of mid-term pregnancy termination using aglepristone in dogs. JSAP 50 (3), 120-123 PubMed.
  • Schäfer-Somi S, Aksoy O A, Beceriklisoy H B et al (2007) Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17beta. Theriogenology 68 (6), 889-895 PubMed.
  • Corrada Y, García P, de la Sota P E et al (2005) Decrease of body temperature after aglepristone treatment in bitches. Anim Reprod Sci 87 (3-4), 295-299 PubMed.
  • Fieni F, Martal J, Marnet P G et al (2001) Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). J Reprod Fertil Suppl 57, 243-248 PubMed.
  • Galac S, Kooistra H S, Butinar J et al (2000) Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Theriogenology 53 (4), 941-950 PubMed.
  • Hubler M, Arnold S (2000) [Prevention of pregnancy in bitches with the progesterone antagonist aglepristone (alizone)]. Schweiz Arch Tierheilkd 142 (7), 381-386 PubMed.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 
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