Canis ISSN: 2398-2942

Aglepristone

Synonym(s): RU 534

Contributor(s): Monica Ptaszynska

Introduction

Name

  • Aglepristone.

Class of drug

  • Progesterone receptor antagonist.

Description

Chemical name

  • (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Molecular formula

  • C29H37NO2

Molecular weight

  • 431.60958

Physical properties

  • Clear yellow oily solution.

Storage requirements

  • Shelf life of 3 years.
  • Once opened must be used within 28 days and discarded if discoloration occurs.
  • As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
  • Protect the bottle from light.

Uses

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Indications

  • Induction of abortion up to 45 days after unintended mating in bitches Mesalliance.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

with diagnostic tests

  • Hematological and biochemical changes (urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST) reported in up to 5% of dogs following injection Blood biochemistry: overview.

Precautions for the personnel handling the product

  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • Pregnant women should handle the product with extreme care.
  • Care should be taken by the veterinary surgeon when administering the product and the person restraining the treated dog to avoid self-injection.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Agaoglu A R, Schafer-Somi S, Kaya D, Kucukaslan I, Emre B, Gultiken N, Mulaz1moglu B S, Colak A, Aslan S (2011)The intravaginal application of misoprostol improves induction of abortion with aglepristone.Theriogenology76(1), 74-82PubMed.
  • Rigau T, Rodriguez-Gil J E, Garcia F, Rivera del Alamo M M (2011)Partial foetal retention following aglepristone treatment in a bitch.Reprod Domest Anim46, 738-741PubMed.
  • Pettersson C H, Tidholm A (2009)Safety and efficacy of mid-term pregnancy termination using aglepristone in dogs.JSAP50(3), 120-123PubMed.
  • Schaefer-Somi S, Aksoy O A, Beceriklisoy H B, Einspanier A, Hoppen H O, Aslan S (2007)Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17Beta.Theriogenology68, 889-895PubMed.
  • Corrada Y, García P, de la Sota PE, Huzman M, Landoni M F, Gobello C (2005)Decrease of body temperature after aglepristone treatment in bitches.Anim Reprod Sci87(3-4), 295-299PubMed.
  • Fieni F, Martal J, Marnet P G, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001)Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534).J Reprod Fertil Suppl57, 243-248PubMed.
  • Galac S, Kooistra H S, Butinar J, Bevers M M, Dieleman S J, Voorhout G, Okkens A C (2000)Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist.Theriogenology53(4), 941-950PubMed.
  • Hubler M, Arnold S (2000)Prevention of pregnancy in bitches with the progesterone antagonist aglepristone (Alizine).Schweiz Arch Tierheilkd142(7), 381-386PubMed.
  • Galac S, Kooistra H S, Butinar J, Bevers M M, Dieleman S J, Voorhour G, Okkens A C (1999)Termination of midgestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist.Theriogenology53, 941-950.

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