Canis ISSN: 2398-2942

Afoxolaner

Synonym(s): NexGard®

Contributor(s): Dwight Bowman, Linda Horspool

Introduction

Name

  • IUPAC.

Class of drug

  • Insecticide and acaricide belonging to the isoxazoline family.

Description

Chemical name

  • 1-Naphthalenecarboxamide, 4-[5- [3-chloro-5- (trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2- trifluoroethyl)amino]ethyl.

Molecular formula

  • C26H17ClF9N3O3

Molecular weight

  • 625.9

Physical properties

  • Finished product: chewable tablets for dogs.

Storage requirements

  • Product as packaged for sale:
    • Store at or below 30°C.

Uses

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Indications

  • Ectoparasiticide. Insecticide. Acaricide. Flea adulticide.
  • Treatment and prevention of flea infestations (Ctenocephalides felis Ctenocephalides felis and C.canis Ctenocephalides canis) for at least 5 weeks.
  • Can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
  • Kills fleas before egg production and therefore prevents household contamination.
  • Treatment and control of several tick species for up to 1 month - depending on the geography -Dermacentor reticulatus Dermacentor reticulatus (Ornate cow or march tick) and D.variabilis (American dog tick), Ixodes ricinus Ixodes ricinus (Castor bean tick) and Ixodes scapularis (Black-legged or deer tick), Rhipicephalus sanguineus Rhipicephalus sanguineus (Brown dog tick), Amblyomma americanum (Lone star tick) and Haemaphysalis longicornis (Cattle, scrub or bush tick).

Administration

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Precautions

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Interactions

with other drugs

  • None known.
  • In a controlled field study in dogs, afoxolaner was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), corticosteroids, NSAIDS, anesthetics, and antihistamines.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Beugnet F, Halos L, Larsen D, Labuschagne M, Erasmus H, Fourie J (2014) The ability of an oral formulation of afoxolaner to block the transmission of Babesia canis by Dermacentor reticulatus ticks to dogs. Parasit Vectors 7, 283 PubMed.
  • Drag M, Saik J, Harriman J, Larsen D (2014) Safety evaluation of orally administered afoxolaner in 8-week-old dogs. Vet Parasitol 201, 198-203 PubMed.
  • Dumont P, Blair J, Fourie J J, Chester T S, Larsen D L (2014) Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodes ricinus. Vet Parasitol 201, 2016-219 PubMed.
  • Dumont P, Gale B, Chester T S, Larsen D L (2014) Curative and preventative efficacy of orally administered afoxolaner againstCtenocephalides canisinfestation in dogs. Vet Parasitol 201, 212-215 PubMed.
  • Hunter J S 3rd, Dumont P, Chester T S, Young D R, Fourie J J, Larsen D L (2014) Evaluation of the curative and preventative efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs. Vet Parasitol 201, 207-211 PubMed.
  • Kondo Y, Kinoshita G, Drag M, Chester T S, Larsen D (2014) Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs. Vet Parasitol 201, 229-231 PubMed.
  • Kunkle B, Daly S, Dumont P, Drag M, Larsen D (2014) Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato. Vet Parasitol 201, 226-228 PubMed.
  • Kunkle B N, Drag M D, Chester T S, Larsen D L (2014) Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs. Vet Parasitol 201, 204-206 PubMed.
  • Mitchell E B, Dorr P, Everett W R, Chester T S, Larsen D (2014) Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs. Vet Parasitol 201, 220-222 PubMed.
  • Mitchell E B, McCall J W, Chester T S, Larsen D (2014) Efficacy of afoxolaner against Ixodes scapularis ticks in dogs. Vet Parasitol 201, 223-225 PubMed.
  • Shoop W L, Hartline E J, Gould B R, Waddell M E, McDowell R G, Kinney J B, Lahm G P, Long J K, Xu M, Wagerle T, Jones G S, Dietrich R F, Cordova D, Schroeder M E, Rhoades D F, Benner E A, Confalone P N (2014) Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Vet Parasitol 201, 179-189 PubMed.
  • Letendre L, Huang R, Kvaternick V, Harriman J, Drag M, Soll M (2014) The intravenous and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs. Vet Parasitol 201, 190-197 PubMed.
  • Otranto D (2014) NEXGARD®. Afoxolaner, a new oral insecticide -acaricide to control fleas and ticks in dogs. Ediotrial. Vet Parasitol 201, 177-178 PubMed.

Other sources of information

Organisation(s)


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