Canis ISSN: 2398-2942

Afoxolaner

Synonym(s): NexGard®

Contributor(s): Dwight Bowman, Linda Horspool

Introduction

Name

  • IUPAC.

Class of drug

  • Insecticide and acaricide belonging to the isoxazoline family.

Description

Chemical name

  • 1-Naphthalenecarboxamide, 4-[5- [3-chloro-5- (trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2- trifluoroethyl)amino]ethyl.

Molecular formula

  • C26H17ClF9N3O3

Molecular weight

  • 625.9

Physical properties

  • Finished product: chewable tablets for dogs.

Storage requirements

  • Product as packaged for sale:
    • Store at or below 30°C.

Uses

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Indications

  • Ectoparasiticide. Insecticide. Acaricide. Flea adulticide.
  • Treatment and prevention of flea infestations (Ctenocephalides felis Ctenocephalides felisandC.canis Ctenocephalides canis) for at least 5 weeks.
  • Can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
  • Kills fleas before egg production and therefore prevents household contamination.
  • Treatment and control of several tick species for up to 1 month - depending on the geography -Dermacentor reticulatus Dermacentor reticulatus(Ornate cow or march tick) andD.variabilis(American dog tick),Ixodes ricinus Ixodes ricinus (Castor bean tick) andIxodes scapularis(Black-legged or deer tick),Rhipicephalus sanguineus Rhipicephalus sanguineus(Brown dog tick),Amblyomma americanum(Lone star tick) andHaemaphysalis longicornis(Cattle, scrub or bush tick).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • None known.
  • In a controlled field study in dogs, afoxolaner was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), corticosteroids, NSAIDS, anesthetics, and antihistamines.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Beugnet F, Halos L, Larsen D, Labuschagne M, Erasmus H, Fourie J (2014)The ability of an oral formulation of afoxolaner to block the transmission ofBabesia canisbyDermacentor reticulatusticks to dogs.Parasit Vectors7, 283PubMed.
  • Drag M, Saik J, Harriman J, Larsen D (2014)Safety evaluation of orally administered afoxolaner in 8-week-old dogs.Vet Parasitol201, 198-203PubMed.
  • Dumont P, Blair J, Fourie J J, Chester T S, Larsen D L (2014)Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodes ricinus.Vet Parasitol201, 2016-219PubMed.
  • Dumont P, Gale B, Chester T S, Larsen D L (2014)Curative and preventative efficacy of orally administered afoxolaner againstCtenocephalides canisinfestation in dogs.Vet Parasitol201, 212-215PubMed.
  • Hunter J S 3rd, Dumont P, Chester T S, Young D R, Fourie J J, Larsen D L (2014)Evaluation of the curative and preventative efficacy of a single oral administration of afoxolaner against cat fleaCtenocephalides felisinfestations on dogs.Vet Parasitol201, 207-211PubMed.
  • Kondo Y, Kinoshita G, Drag M, Chester T S, Larsen D (2014)Evaluation of the efficacy of afoxolaner againstHaemaphysalis longicornison dogs.Vet Parasitol201, 229-231PubMed.
  • Kunkle B, Daly S, Dumont P, Drag M, Larsen D (2014)Assessment of the efficacy of orally administered afoxolaner againstRhipicephalus sanguineus sensulato.Vet Parasitol201, 226-228PubMed.
  • Kunkle B N, Drag M D, Chester T S, Larsen D L (2014)Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs.Vet Parasitol201, 204-206PubMed.
  • Mitchell E B, Dorr P, Everett W R, Chester T S, Larsen D (2014)Efficacy of afoxolaner againstDermacentor variabilisticks in dogs.Vet Parasitol201, 220-222PubMed.
  • Mitchell E B, McCall J W, Chester T S, Larsen D (2014)Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol201, 223-225PubMed.
  • Shoop W L, Hartline E J, Gould B R, Waddell M E, McDowell R G, Kinney J B, Lahm G P, Long J K, Xu M, Wagerle T, Jones G S, Dietrich R F, Cordova D, Schroeder M E, Rhoades D F, Benner E A, Confalone P N (2014)Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.Vet Parasitol201, 179-189PubMed.
  • Letendre L, Huang R, Kvaternick V, Harriman J, Drag M, Soll M (2014)The intravenous and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs.Vet Parasitol201, 190-197PubMed.
  • Otranto D (2014)NEXGARD®. Afoxolaner, a new oral insecticide -acaricide to control fleas and ticks in dogs. Ediotrial.Vet Parasitol201, 177-178PubMed.

Other sources of information

Organisation(s)


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