Canis ISSN: 2398-2942

Therapeutics: oral chondroprotectants

Synonym(s): Chondromodulating drugs, nutraceuticals

Contributor(s): Brian Beale, John J Haburjak, Lauren Trepanier


  • Includes 5 types of drugs:
  • Classified as:
    • Slow-acting drugs in osteoarthritis Arthritis: osteoarthritis (SADOA).
      • Symptomatic slow-acting drugs in osteoarthritis (SYSADOA).
      • Disease-modifying osteoarthritis drugs (DMOAD).
    • Chondromodulating drugs.
    • Nutraceuticals Nutraceuticals: principles and uses (glucosamines, chondroitin sulfate, ASU).
      Unity in quality, grade and quantity (strength) cannot be guaranteed or easily verified for nutraceuticals.Equivalency between different product labels is not easily compared.Nutraceuticals cannot be sold with the claim of efficacy in the treatment of osteoarthritis.


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Omega-3 fatty acids

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Further Reading


Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bauer J E (2012) Therapeutic use of fish oils in companion animals. JAVMA 239 (11), 1441-1451 PubMed.
  • Boileau C, Martel-Pelletier J, Caron J et al (2009) Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13. Arthritis Res Ther 11 (2), R41 PubMed.
  • Nganvongpanit K, Pothacharoen P, Suwankong N et al (2009) The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial. J Vet Sci 10 (3), 239-247 PubMed.
  • Au R Y, Al-Talib T K, Au A Y et al (2007) Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, 1L-1beta, Cox-2, iNOS gene expression , and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthritis Cartilage 15 (11), 1249-1255 PubMed.
  • Chan P S, Caron J P, Rosa G J et al (2005) Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants. Osteoarthritis Cartilage 13 (5), 387-394 PubMed.
  • Beale B S (2004) Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Am Small Anim Pract 34 (1), 271-289 PubMed.
  • Jauernig S, Schweighauser A, Reist M et al (2001) The effects of doxycycline on nitric oxide and stomelysin production in dogs with cranial cruciate ligament rupture. Vet Surg 30 (2), 132-139 PubMed.
  • Canapp S O Jr., McLaughlin R M Jr., Hoskinson J J, Roush J K & Butine M D (2000) Scintigraphic evaluation of glucosamine hydrochloride‚Äč and chondroitin sulfate as treatment for acute synovitis in dogs. Am J Vet Res 60 (12), 1552-1557 PubMed.
  • Davidson G (2000) Glucosamine and chondroitin sulfate. Compend Contin Educ Pract Vet 22 (5), 454-458 VetMedResource.
  • Anderson M A (1999) Oral Chondroprotectants. Part I. Compend Contin Educ Pract Vet 21, 601-609.
  • Anderson M A (1999) Oral Chondroprotectants. Part IICompend Contin Educ Pract Vet 21, 861-865.
  • McNamara P S, Johnston S A & Todhunter R J (1997) Slow-acting disease-modifying osteoarthritis agents. Vet Clin N Amer Sm Anim Pract 27 (4), 863-881 PubMed.
  • Vaughan-Scott T & Taylor J H (1997) The pathophysiology and medical management of canine osteoarthritis. J S Afr Vet Assoc 68 (1), 21-25 PubMed.

Other sources of information

  • Demko J L, Phan P V, Kramer E A, McLaughlin R & Frondoza C G (2007) Inhibition of prostaglandin e-2 production in chondrocyte microcarrier spinner cultures by the combination of avocado soy unsaponifiables, chondroitin sulfate and glucosamine. Proceedings of the 34th Annual Conference of the Veterinary Orthopedic Society, 25.
  • Hayashi K, Hao Z, Manley PA & Muir P (2003) Inhibition of collagenolytic proteinases by tetracycline analogues: a potential treatment for cruciate disease of the dog. Scientific Presentation of Abstracts. 13th Annual American College of Veterinary Surgeons Symposium, October 9-12, 2003, Washington DC. Vet Surg 32, 479-500.
  • Budsberg S C, Todhunter R J & McNamara P S Jr (1999) Use of chondromodulating drugs and substances in the prevention and treatment of osteoarthritis in dogs. In: Kirk's Current Veterinary Therapy. XIII edn. Ed John Bonagura. W B Saunders, Philadelphia, pp 1018-1022.
  • Plumb D C (Ed.) Veterinary Drug Handbook. 3rd edn. Iowa State Press, Ames.