Canis ISSN: 2398-2942

Therapeutics: gastrointestinal system

Contributor(s): Juan Escala, Linda Horspool, Lauren Trepanier

Antidiarrheal Drugs

  • * Indicates product not licensed for use in this species.
  • Causes of diarrhea Diarrhea: chronic , include diet, infection, neoplasia/dysplasia, inflammation/malabsorption, exocrine pancreatic insufficiency, drug treatment and stress.
  • Treatment must address causative agent, supportive therapy (fluid therapy Fluid therapy , electrolyte replacement Fluid therapy ), and diet.
  • Antibiotics Therapeutics: antimicrobial drug , indicated if diarrhea due to bacterial overgrowth or mucosal barrier disrupted, eg neomycin Neomycin , some sulphonamides, some nitrofurans Nitrofurans
  • Metronidazole Metronidazole , used as an adjunct to corticosteroids for small intestinal inflammatory bowel disease.
  • Probiotics Probiotics and intestinal health to help re-establish normal intestinal microbiota.

Anti-emetics and emetics

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Laxatives

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Modulators of intestinal motility

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Antacids and ulcer-healing drugs

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Others

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Further Reading

Publications

Refereed papers
  • Recent references fromPubMed.
  • Le Traon G, Burgaud S, Horspool L J (2009)Pharmacokinetics of cimetidine in dogs after oral administration of cimetidine tablets.Vet Pharmacol Ther32(3), 213-218PubMed.
  • Narishetty S T et al(2009)Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection. Vet Ther10(3), 93-102PubMed.
  • Brown A J, Otto C M (2008)Fluid therapy in vomiting and diarrhea. Vet Clin North Am Small Anim Pract38(3), 653-675, xiiiPubMed.
  • Conder G A et al(2008)Efficacy and safety of maropitant, a selective neurokinin 1 receptor antagonist, in two randomized clinical trials for prevention of vomiting due to motion sickness in dogs. J Vet Pharmacol Ther31(6), 528-532PubMed.
  • Ramsey D S et al(2008)Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther31(6), 538-543PubMed.
  • Sedlacek H S et al(2008)Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs. J Vet Pharmacol Ther31(6), 533-537PubMed.
  • Benchaoui H A et al(2007)Efficacy of maropitant for preventing vomiting associated with motion sickness in dogs. Vet Rec161(13), 444-447PubMed.
  • de la Puente-Redondo V A et al(2007a)The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe. J Small Anim Pract48(2), 93-98PubMed.
  • de la Puente-Redondo V A et al(2007b)Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs. Am J Vet Res68(1), 48-56PubMed.
  • Vail D M et al(2007)Efficacy of injectable maropitant (Cerenia) in a randomized clinical trial for prevention and treatment of cisplatin-induced emesis in dogs presented as veterinary patients. Vet Comp Oncol5(1), 38-46PubMed.
  • Wilson D V, Tom Evans A, Mauer W A (2007)Pre-anesthetic meperidine: associated vomiting and gastroesophageal reflux during the subsequent anesthetic in dogs. Vet Anaesth Analg34(1), 15-22PubMed.
  • Wilson D V, Evans A T, Miller R (2005)Effects of preanesthetic administration of morphine on gastroesophageal reflux and regurgitation during anesthesia in dogs. Am J Vet Res66(3), 386-390PubMed.
  • Valverde A et al(2004)Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs. Vet Anaesth Analg31(1), 40-45PubMed.
  • Hikasa Y et al(1986)Antagonism of the emetic action of xylazine by alpha-adrenoceptor blocking agents. Eur J Pharmacol130(3), 229-235.

Other sources of information


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