Canis ISSN: 2398-2942

Therapeutics: anti-neoplastic agent

Synonym(s): Chemotherapy, Cytotoxic agent

Contributor(s): William Brewer Jr, Lauren Trepanier, Isabelle Desmas-Bazelle

Introduction

  • Most cytotoxic agents act upon process of cell growth and division: potent and potentially dangerous. 
Do not use without consulting specialist oncologist. Refer to chemotherapy safety administration Chemotherapy: safe handling.
  • Indications and goal of therapy: 
    • Primary induction chemotherapy: for lymphoproliferative Lymphoproliferative disease and myeloproliferative Myeloproliferative tumor disorders (hematopoietic cancers) or for a palliative role in advanced/metastatic cancers with no alternative treatment options. 
    • Primary neoadjuvant chemotherapy: to decrease tumor size and/or clinical stage prior to surgery and/or radiotherapy.
    • Adjuvant treatment: after surgery and/or radiotherapy (to treat residual tumor cells or micrometastasis).

Cytotoxic drugs

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Other cytotoxic drugs

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Sex hormones and hormone antagonists

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Smith A N, Klahn S, Phillips B, Parshley L, Bennett P (2018) ACVIM small animal consensus statement on safe use of cytotoxic chemotherapeutics in veterinary practice. J Vet Intern Med 32(3), 904-913 PubMed Full Article
  • Biller B, Berg J, Garrett L et al (2016) AAHA oncology guidelines for dogs and cats. J Am Anim Hosp Assoc 52, 182-204 PubMed Full Article.
  • MacDonald V (2009) Chemotherapy: managing side effects and safe handling. Can Vet J 50(6),  665-668 PubMed Full Article.

Other sources of information

  • Gustafson D L, Bailey D B (2020) Cancer chemotherapy. In: Small animal clinical oncology. 6th edn. Eds Withrow & MacEwen’s. Elsevier Saunders, St. Louis. pp 182-208.


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