Canis ISSN: 2398-2942 Standard reasons for failure in a treatment Reasons Reasons Incorrect diagnosis, eg Acute clinical presentation demanding immediate therapy- before sufficient laboratory or other work-up was possible. Atypical form of a common disease- not recognized by the clinician. Typical case of an uncommon/rare disease- not included within the clinician's differential diagnostic list. Client failings, eg Inaccurate "witness", ie provided unreliable history details to the clinician. Non-compliancewith clinician's instructions, due to: Did not fully understandwhat to do. Unwilling to reveal uncertaintyabout what to do. Ignored veterinary instructions- preferred, or persuaded by others, to use alternative or additional medication or other measures which compromised the clinician's case strategy. Had difficulty administering medication, eg by mouth to an uncooperative cat. Mis-read medication instructions, eg "2 tablets to be given twice daily" interpreted as 2 tablets total per day but divided and given as 1 every ~12 hours. Hence animal underdosed. If suspected, calculate how much should remain from the quantity of medication originally dispensed and how long ago. Cross-check by casually asking the client how much medication remains. A significant discrepancy suggests underdosing. Instruction "2 tablets to be given every 12 hours" may be less confusing. Further Reading PublicationsRefereed papers Recent references from PubMed and VetMedResource.