Canis ISSN: 2398-2942

Natriuretic peptides

Contributor(s): Barrett Bulmer

Introduction

  • The natriuretic peptides (NP) are a group of structurally related but genetically distinct peptides that induce vasodilation and natriuresis.
  • NPs are released in response to physiological and pathological stimulation, including:
    • Exercise.
    • Hypoxia.
    • Ischemia.
    • Sepsis Shock: septic.
    • Increased cardiac wall stress.
    • Chamber dilatation/stretch.
  • Although atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been most extensively studied, C-type natriuretic peptide (CNP) and dendroaspis natriuretic peptide (DNP) have also been identified.

Pathophysiology

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Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)

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Elimination and measurement

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Use of NP assays

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Further Reading

Publications

Refereed papers
  • Recent references fromPubMed.
  • Chetboul V, Tessier-Vetzel D, Escriou C, Tissier R, Carlos C, Boussouf M, Pouchelon J L, Blot S, Derumeaux G (2004)Diagnostic potential of natriuretic peptides in the occult phase of golden retriever muscular dystrophy cardiomyopathy. J Vet Intern Med18(6), 845-850PubMed.
  • Sisson D D (2004)Neuroendocrine evaluation of cardiac disease. Vet Clin North Am Small Anim Pract34(5), 1105-1126. ReviewPubMed.
  • Han B, Hasin Y (2003)Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1. Cardiovasc Drugs Ther17(1), 41-52.
  • MacDonald KA, Kittleson MD, Munro C, Kass P (2003)Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure. J Vet Intern Med17(2), 172-177PubMed.
  • Tidholm A, Haggstrom J, Hansson K (2001)Effects of dilated cardiomyopathy on the renin-angiotensin-aldosterone system, atrial natriuretic peptide activity, and thyroid hormone concentrations in dogs. Am J Vet Res62(6), 961-967PubMed.
  • Kitagawa H, Kitoh K, Inoue H et al(2000)Plasma renin activities, angiotensin II concentrations and cardiopulomary function values in dogs with severe heartworm diseaseJ Vet Med Sci62(4), 453-455PubMed.
  • Haggstrom J et al(1997)Effects of naturally acquired decompensated mitral valve regurgitation on the RAA system and ANP concentration in dogs. Am J Vet Res58, 77-82.

Other sources of information

  • Oyama M A & Sisson D D (2006)Predictive value of natruiretic peptide and cardiac troponin-I testing in dogs with moderate to severe congenital subaortic stenosis. J Vet Intern Med20(3), 733 (Abstract).
  • Prosek R, Sisson D D, Oyama M A et al(2004)Use of plasma ANP, BNP, endothelin-1 and troponin-I levels in distinguishing between cardiac and non-cardiac causes of acute dyspnea in dogs. J Vet Intern Med18(3), 810-811 (Abstract).


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