Canis ISSN: 2398-2942

Liver disease investigation

Contributor(s): Kyle Braund, James Simpson, Andrew Kent

Introduction

  • Accurate clinical evaluation of the liver can be accomplished by a series of diagnostic procedures.
  • Physical examination and a complete history of the patient are important in the diagnosis of liver damage - most signs are relatively non-specific.
  • The history is particularly important in differentiating acute Liver: acute disease from chronic disease Liver: chronic disease - overview.
  • Examination of urine and blood samples is essential in the diagnostic process.
  • Remember both primary liver disease (cirrhosis Liver: cirrhosis, toxic hepatitis Liver: toxic hepatitis) occur as do secondary disorders (Cushing's disease, heart disease).

Clinical presentation of liver disease

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Diagnostic imaging

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Laboratory investigation

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Biochemical testing

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Cytological/Histopathological evaluation

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Is the liver involvement primary or secondary?

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Prognosis

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Gaschen L (2009) Update on Hepatobiliary Imaging. Vet Clin North Am Small Anim Pract 39 (3), 439-467 PubMed.
  • Center S (2007) Interpretation of Liver Enzymes. Vet Clin North Am Small Anim Pract 37 (2), 297-333 PubMed.
  • Roth L (2001) Comparison of liver cytology and biopsy diagnoses in dogs and cats: 56 cases. Vet Clin Pathol 30 (1), 35-38 PubMed.
  • Center S (1999) Chronic liver disease: current concepts of disease mechanisms. JSAP 40 (3), 106-114 PubMed.

Other sources of information

  • Center S, Schermerhorn T, Lyman R, Phillips L (2000) Hepatoportal Microvascular Dysplasia. In: Current Veterinary Therapy XIII. Bonagura J (ed), W B Saunders, Philadelphia. pp 682-686.
  • Hess P R & Bunch S E (2000) Diagnostic Approach to Hepatobiliary Disease. In: Current Veterinary Therapy XIII. Bonagura J (ed), W B Saunders, Philadelphia. pp 659-664.


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