Canis ISSN: 2398-2942

Cancer therapy: overview

Contributor(s): Jane Dobson, Suzanne Murphy

Introduction

  • The conventional treatment options for pets with cancer include surgery, chemotherapy Chemotherapy: general principles , and radiotherapy Radiotherapy. Surgery is usually the most effective means of removal of localized tumors and offers the opportunity of cure for all benign tumors and many low grade malignant tumors, eg basal cell carcinoma Skin: basal cell tumor. Radiotherapy may be used alone or as an adjunct to surgery but also really addresses only local disease, whereas chemotherapy is indicted in the treatment of systemic malignant tumors, eg lymphoma Lymphoma or as an adjunct to surgery in the treatment of highly metastatic tumors, eg osteosarcoma Osteosarcoma.
  • Immunotherapy (immunomodulation), photodynamic therapy, cryosurgery and hyperthermia are other options for some cancer types.

Photodynamic therapy

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Veterinary clinical results

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Conclusion and future directions

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Immunomodulation

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Vail D (2013) Levels of evidence in canine oncology trials - a case in point. Vet Comp Oncol 11(3), 167-168 PubMed.
  • Ottnod J M et al (2013) A retrospective analysis of the efficacy of Oncept vaccine for the adjunct treatment of canine oral malignant melanoma. Vet Comp Oncol 11(3), 219-229 PubMed.
  • Grosenbaugh D A, Leard A T, Bergman P J, Klein M K, Maleo K et al (2011) Safety and efficacy of a xenogenic DNA vaccine encoding for human tyrosinase as adjuvant treatment for oral melanoma in dogs following surgical excision of the primary tumour. Am J Vet Res 72, 1631-1638 PubMed.
  • Bexfield N H, Stell A J, Gear R N, & Dobson J M (2008) Photodynamic therapy of superficial nasal planum squamous cell carcinomas in cats: 55 cases. JVIM 22, 1385-1389 PubMed.
  • Morton C A, McKenna K E, Rhodes L E (2008) British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group. Guidelines for topical photodynamic therapy: update. British Journal of Dermatology 159 (6),1245-1266 PubMed.
  • Gill V L, Bergman P J, Baer K E, Craft D, Leung C (2008) Use of imiquimod 5% cream (Aldara) in cats with multicentric squamous cell carcinoma in situ: 12 cases (2002 2005). Veterinary & Comparative Oncology 6(1), 55-64 PubMed.
  • Nogueira S A F, Torres S M F, Malone E D, Diaz S F, Jessen C, Gilbert S (2006) Efficacy of imiquimod 5% cream in the treatment of equine sarcoids: a pilot study. Vet Dermatol 17(4) 259 -265.
  • Jourdier T-M, Moste C, Bonnet M-C, Delisle F, Tafani J-P, Devauchelle P, Tartaglia J, Moingeon P (2003) Local immunotherapy of spontaneous feline fibrsarcomas using recombinant poxviruses expressing interleukin 2 (IL2). Gene Therapy 10, 2126-2132 PubMed.
  • Stell A J, Dobson J M, Langmack K (2001) Photodynamic therapy of feline superficial squamous cell carcinoma using topical 5-aminolaevulinic acid. JSAP 42, 164-169 PubMed.

Other sources of information


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