Canis ISSN: 2398-2942

Anesthetic induction: overview

Contributor(s): Jo Murrell, Sheilah Robertson

Introduction

  • General anesthesia: a state of unconsciousness produced by controlled, reversible intoxication of the central nervous system during which the patient neither perceives nor recalls noxious stimuli.
  • Anesthetic agent: a substance which produces loss of consciousness in a controllable manner.
  • Anesthetic induction: the state achieved when anesthetic agent concentration in the brain is high enough.
  • Induction can be achieved using (alone or in combination):
    • Injectable agents administered intravenously (IV) or intramuscularly (IM).
    • Volatile agents inhaled with a carrier gas.

Injectable Agents

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Volatile agents

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Pasloske K, Sauer B, Perkins N & Whittem (2009) Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan at a clinical dose. J Vet Pharmacol Ther 32, 510-513 PubMed.
  • Ferre P J, Pasloske K, Whittem T, Ranasinghe M G, Li Q, Lefebvre H P (2009) Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU. Vet Anaesth Analg 33, 229-236 PubMed.
  • Sams R A et al (1988) Effects of phenobarbital on thiopental pharmacokinetics in greyhounds. Am J Vet Res 49(2), 245-249.
  • Robinson E P et al (1986) Barbiturate anesthesia in greyhound and mixed-breed dogs - comparative cardiopulmonary effects, anesthetic effects, and recovery rates. Am J Vet Res 47(10), 2105-2112.
  • Sams R A et al (1985) Comparative pharmacokinetics and anesthetic effects of methohexital, pentobarbital, thiamylal, and thiopental in Greyhound dogs and non-Greyhound, mixed breed dogs. Am J Vet Res 46(8), 1677-1683.


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