ISSN 2398-2969      

Uveodermatological syndrome

icanis

Synonym(s): Vogt-Koyanagi-Harada (VKH-like syndrome


Introduction

  • Cause: autoimmune.
  • Signs: anterior uveitis, chorioretinitis, poliosis, vitiligo.
  • Diagnosis: signalment, clinical signs, dermatological histopathology.
  • Treatment: systemic immunsuppressive drugs.
  • Prognosis: guarded.

Pathogenesis

Etiology

  • Not completely understood.
  • Autoimmune disease directed at melanocytes.

Predisposing factors

General
  • Breed.

Pathophysiology

  • Cell-mediated destruction of melanocytes.
  • There is some evidence that the ocular lesions mainly result from a beta-cell and macrophage response (Th2 immunity) whereas the skin lesions are mediated by T-cells and macrophages (Th1 immunity) (Carteret al2005).
  • The canine leukocyte antigen DLA-DQA1*00201 has been associated with an increased risk for uveodermatological syndrome than other DLA class II alleles.

Timecourse

  • The disease is chronic and life-long treatment is usually required.

Epidemiology

  • Relates to breed predisposition and distribution within a given population.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Horikawa T, Vaughan R K, Sargent S J et al (2013) Pathology in practice. Uveodermatologic syndrome. JAVMA 242 (6), 759-761 PubMed.
  • Angles J M, Famula T R, Pedersen N C (2005) Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201. Tissue Antigens 66 (6), 656-665 PubMed.
  • Carter W J, Crispin S M, Gould D J et al (2005) An immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs. Vet Ophthalmol (1), 17-24 PubMed.

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