Canis ISSN: 2398-2942

Stomach: lymphocytic plasmacytic gastritis

Contributor(s): Audrey K Cook, James Simpson

Introduction

  • A chronic inflammatory disease of the stomach.
  • Cause: rarely determined but may include dietary hypersensitivity or intolerance.
  • Concurrent intestinal involvement may occur.
  • Diagnosis: biopsy findings; exclusion of other causes of gastric inflammation.
  • Treatment: hypoallergenic diet, prednisolone, anti-emetics; azathioprine in severe cases.
  • Prognosis: generally good.

Pathogenesis

Etiology

  • Majority of cases are described as idiopathic.
  • Dietary hypersensitivity Skin: food hypersensitivity /food intolerance is thought to be important in some cases.
  • Some cases have concurrentHelicobacterinfection Helicobacter spp - significance not known.

Predisposing factors

General
  • None identified.

Pathophysiology

  • An inflammatory reaction to an unknown stimulas results in the accumulation of lymphocytes and plasma cells within the lamina propria.
  • Gastric lymphosarcoma Lymphoma may appear similar to lymphocytic plasmacytic gastritis in its early stages.

Timecourse

  • Months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lidbury J A, Suchodolski J S & Steiner J M (2009) Gastric histopathologic abnormalities in dogs: 67 cases (2002-2007). JAVMA 234 (9), 1147-1153 PubMed.
  • Leib M S, Duncan R B & Ward D L (2007) Triple antimicrobial therapy and acid suppression in dogs with chronic vomiting and gastric Helicobacter spp. JVIM 21 (6), 1185-1192 PubMed.

Organisation(s)

  • Department of Veterinary Clinical Studies, Easter Bush Veterinary Center, Near Roslin, Midlothian, UK.


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