Canis ISSN: 2398-2942

Stomach: eosinophilic gastritis

Contributor(s): James Simpson, Kenneth Simpson

Introduction

  • Rare, eosinophilic infiltration of gastric mucosa - usually diffuse.
  • May also affect small and large intestine.
  • Cause: ?immune-mediated due to allergic/parasitic cause.
  • Signs: chronic vomiting, often weight loss, hematemesis.
  • Diagnosis: histopathology of gastric mucosa. Persistent circulating eosinophilia.
  • Treatment: prednisolone initially, dietary for long term control. Anthelmintics to rule out parasitism.
  • Prognosis: reasonable.

Pathogenesis

Etiology

  • Unknown.
  • Immune-mediated disease associated with dietary factors or parasites.

Pathophysiology

  • Eosinophilic infiltration, usually in mucosa but can affect other layers of stomach.
  • Damage to gastric mucosal barrier may → ulceration.
  • Thickening/granuloma in pyloric region → mechanical outflow obstruction (rare).

Timecourse

  • Months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johnson S E (1992) Canine eosinphic gastroenterocolitis. Semin Vet Med Surg 7 (2), 145-52 PubMed.
  • Stanton M E & Bright R M (1989) Gastroduodenal ulceration in dogs - retrospectice study of 43 cases and literature review. JVIM 3 (4), 238-244 PubMed.


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