Canis ISSN: 2398-2942

Spleen: neoplasia

Synonym(s): Splenomegaly

Contributor(s): Kyle Braund, William Brewer Jr

Introduction

  • Cause: primary neoplastic lesions, metastatic disease, or manifestation of systemic involvement.
  • Signs: splenomegaly (localized/generalized) and non-specific signs of ill health.
  • Diagnosis: ultrasonography, biopsy.
  • Treatment: chemotherapy and/or splenectomy.
  • Prognosis: guarded.

Pathogenesis

Etiology

Pathophysiology

  • Infiltration of the spleen with neoplastic cells constitutes one of the most common causes of splenomegaly in dogs.

Timecourse

  • Depends on underlying disease - can be days to months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Fulmer A K, Maudlin G E (2007) Canine histocytic neoplasia: an overview. Can Vet J 48 (10), 1041-1043, 1046-1050 PubMed.
  • Skorupski K, Clifford C, Paoloni M et al (2007) CCNU for the treatment of dogs with histocytic sarcoma. JVIM 21 (1), 121-126 PubMed.
  • Affolter V K, Moore P F (2002) Localized and disseminated histocytic sarcoma of dendritic cell origin in dog. Vet Path 39 (1), 74-83 PubMed.
  • Spangler W L & Kass P H (1999) Splenic myeloid metaplasia, histiocytosis and hypersplenism in the dog (65 cases). Vet Pathol 36 (6), 583-593 PubMed.
  • Spangler W L & Culbertson M R (1992) Prevalence, type and importance of splenic diseases in dogs - 1480 cases (1985-1989). JAVMA 200 (6), 829-834 PubMed.

Other sources of information

  • Couto C G & Hammer A S (1995)diseases of the lymph nodes and the spleen.In:Textbook of Veterinary Internal Medicine. 4th edn. Ettinger S J & Feldman E C (eds). W B Saunders, Philadelphia. pp 1930-1946.


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