ISSN 2398-2969      

Skin: subcorneal pustular dermatosis

icanis
Contributor(s):

David Scarff


Introduction

  • Rare if differential diagnoses carefully ruled out.
  • Cause: unknown, but probably immune-mediated.
  • Breed: 40% of cases in miniature Schnauzer.
  • Diagnosis: no definitve test; rule out differentials.
  • Treatment: dapsone most effective.
  • Prognosis: good if responds to treatment.

Pathogenesis

Etiology

  • Not known, but likely to be immune-mediated.

Pathophysiology

  • Immune complexes and IgA in stratum corneum → neutrophil chemotaxis and subcorneal pustule formation.
  • IgA and immune complexes have been demonstrated in the skin which may lead to neutrophil chemotaxis and subsequent subcorneal pustule formation.

Timecourse

  • Pustules appear rapidly and are transient.
  • Disease is chronic unless treated.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Kalaher K M & Scott D W (1990) Subcorneal pustular dermatosis in dogs and human beings. Comparative aspects. J Am Acad Dermatol 22 (6 Pt 1), 1023-8 PubMed.

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