Canis ISSN: 2398-2942

Skin: plasmacytoma

Synonym(s): plasma cell tumor, extramedullary plasmacytoma

Contributor(s): Kyle Braund, Judy Morris

Introduction

  • Usually occur in skin and oral cavity but also reported in GI tract, spleen, LNs.
  • Rare.
  • Usually benign.
  • Unrelated to multiple myeloma Myeloma and may be associated (rare) with paraneoplastic disease (hyperproteinemia).
  • Cause: neoplastic proliferation of plasma cells at a site distant from bone marrow.
  • Signs: found in skin and oral cavity, but also reported in GI tract, spleen, lymph nodes. Usually solitary, dome-shaped alopecic nodules in skin but can be multiple.
  • Predilection sites on head, feet, lips and ear canal but can occur anywhere.
  • Diagnosis: histopathology.
  • Treatment: surgical resection, radiotherapy, chemotherapy.
  • Prognosis: good for skin lesions.

Pathogenesis

Pathophysiology

  • Solitary proliferation of neoplastic plasma cells at a site distant from the bone marrow → rarely associated with paraneoplastic disease (monoclonal gammopathy).
  • GI forms more aggressive than skin form and may metastasize.
  • Solitary proliferation of neoplastic plasma cells at a site distant from the bone marrow.
  • Local cutaneous or oral problem usually.
  • May occur at multiple sites in skin (not necessarily metastases).
  • Spread to local lymph nodes quite common if in GI tract (not usually if in skin).
  • May be associated with paraneoplastic disease (monoclonal gammopathy).

Timecourse

  • Weeks.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Chaffin K et al (1998) Extramedullary plasmacytoma in the trachea of a dog. JAVMA 212 (10), 1579-1581 PubMed.
  • Mills J A (1997) Oral mass (plasmocytoma) in an old dog. Aust Vet J 75 (2), 106-107 PubMed.
  • Clarke G N, Berg J, Engler S J and Bronson R T T (1992) Extramedullary plasmacytomas in dogs - results of surgical escision in 131 cases. JAAHA 28 (2), 105-111 VetMedResource.
  • Lucke V (1987) Primary cutaneous plasmacytomas in the dog and cat. JSAP 28 (1), 49-55 VetMedResource.

Other sources of information

  • Goldschmidt M H & Shofer F S (1992)Cutaneous plasmacytoma in skin tumours of the dog and cat.Pergamon Press, Oxford. Chapter30, 265-270.


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