Canis ISSN: 2398-2942

Skin: keratinization disorders

Synonym(s): Seborrhea; Disorders of cornification

Contributor(s): Rosanna Marsella, David Scarff, David Godfrey

Introduction

  • Disorders of keratinization or cornification alter the surface appearance of the skin by affecting the structure and function of the epidermis. Proliferation, differentiation and desquamation of the stratum corneum or epidermal lipid formation are abnormal. Hyperkeratosis with parakeratotic or orthokeratotic changes is usual and shows as skin that is visibly thickened as well as being thickened on histopathology. Occasionally hypokeratosis is present - usually visible only on histopathology.
  • Keratinization defects also affect transepidermal water loss rates.
  • Cause: congenital or acquired.
  • Signs: may be localized or generalized.

Pathogenesis

Etiology

Treatment

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Campbell K L (1994) Seborrheic skin disorders and their treatment in dogs. Clinical Dermatology 12 (4), 551-558 PubMed.
  • Shanley K J (1990) The seborrheic disease complex. An approach to underlying causes and therapies. Vet Clin North Am Small Anim Pract 20 (6), 1557-1577 PubMed.

Other sources of information

  • Miller W H, Griffin C E & Campbell K L (2013) Topical formulation. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 117.
  • Miller W H, Griffin  C E & Campbell K L (2013) Synthetic retinoids. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 139.
  • Miller W H, Griffin C E & Campbell K L (2013) Keratinization defects. In: Muller & Kirk’s Small Animal Dermatology 7th Edition. Elsevier Mosby, St Louis pp 630.


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