ISSN 2398-2969      

Skin: idiopathic/granulomatous sebaceous adenitis

icanis
Contributor(s):

Charlie Walker

Synonym(s): Sebaceous adenitis


Introduction

  • Causes: an inflammation of and around the sebaceous glands leading to loss of these structures.
  • Signs: dry skin, scaling and hair loss.
  • Certain breeds are predisposed, but has been seen in over 60 breeds plus crossbreeds.
  • Etiology and pathogenesis unclear.
  • Treatment: shampoos, sprays, immunomodulatory therapy and antibacterials.
  • Prognosis: guarded but variable.

Pathogenesis

Etiology

  • Pedigree studies in some breeds have demonstrated an autosomal recessive mode of transmission.

Pathophysiology

  • Poorly understood but various speculative theories proposed.
  • Speculations include:
    • Sebaceous gland destruction is developmental and genetically inherited defect.
    • Sebaceous gland destruction is an immune mediated (T cell mediated) or auto-immune disease directed against a component of the sebaceous glands.
    • The initial defect is a keratinization abnormality with subsequent obstruction of the sebaceous ducts resulting in sebaceous adenitis.
    • There is an abnormality in lipid metabolism causing reduced production of sebum which in turn leads to abnormal keratinization and follicular atrophy.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lortz J et al (2010) A multicentre placebo-controlled clinical trial on the efficacy of oral ciclosporin A in the treament of canine idiopathic sebaceous adenitis in comparison with conventional therapy. Vet Dermatol 21 (6), 593-601 PubMed.
  • Linek M et al (2005) Effects of cyclosporine A on clinical and histopatholgical abnormalities with sebaceous adentitis. JAVMA 226 (1), 59-64 PubMed.
  • Kuhl K A (1996) Newly reported skin diseases. Vet Med 91 (11), 1007-1020 VetMedResource.
  • White S D et al (1995) Sebaceous adentitis in dogs and results of treatment with isoretinoin and etretinate: 30 cases (1990-1994). JAVMA 207 (2), 197-200 PubMed.

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